|Following up on the highly successful UltraViolet Imaging Telescope(UVIT) instrument onboard Astrosat, the Indian astronomical community interested in the UV domain has submitted a proposal for a next-generation UV-Optical mission, the INdian Spectroscopic and Imaging Space Telescope (INSIST) in response to a call for proposals by the Indian Space Research Organisation. This proposal is led by the Indian Institute of Astrophysics partnering with ARIES, IUCAA, PRL, TIFR, Christ University and other national and international institutions. The INSIST science team has identified some of the key science topics that define the telescope baseline specifications and the choice of instruments for the observatory. The combination of high spatial resolution, wide-field UV-optical photometry and medium resolution multi-object spectroscopy from INSIST will be powerful for addressing a wide range of astrophysical questions. This poster highlights some of these key science cases and discusses their impact and possible synergy with the upcoming ground and space-based facilities.